DL-Panthenol CAS 16485-10-2 | Bulk Vitamin B5 Supplier

1. Efficient Conversion to Vitamin B5 for Biological Activity

After penetrating the skin or hair, DL-Panthenol rapidly crosses the stratum corneum and is efficiently converted to Vitamin B5 (pantothenic acid) under the action of enzymes. Vitamin B5 is an essential component of coenzyme A, which is required for maintaining skin health and metabolism, and can effectively promote skin cell metabolism.

2. Deep Penetrating Moisturization

DL-Panthenol is a deep-penetrating humectant with a small molecular weight of approximately 205. It can easily penetrate the stratum corneum and exert its effects deep into the epidermis and even hair follicles.

3. Superior Repair & Anti-Inflammatory Efficacy

After percutaneous absorption, DL-Panthenol promotes the proliferation and migration of epidermal epithelial cells, accelerating the healing of minor wounds. It also exhibits significant anti-inflammatory effects, effectively relieving skin irritation, itching, erythema and inflammation.

4. Excellent Biocompatibility & Safety

As a water-soluble vitamin derivative, DL-Panthenol has extremely low acute toxicity and is non-sensitizing, making it gentle and friendly to all skin types.

5. High Formulation Flexibility

DL-Panthenol effectively binds to anionic and cationic surfactants, allowing it to deposit effectively on the skin and hair in rinse-off products such as shampoos and facial cleansers, ensuring its efficacy is delivered. It has excellent compatibility with anionic, cationic and non-ionic surfactants, facilitating formulation design.

6. Excellent Physical & Chemical Stability

Within the recommended dosage range, DL-Panthenol has minimal impact on the pH value of the formulation system and operates effectively over a wide temperature range. When stored in a sealed container under dry and light-protected conditions, it has a long shelf life.

Powder form: Recommended storage at 0-4°C

Liquid form: Sealed storage at room temperature

1. Skincare Products

Improves skin barrier function, reduces inflammatory responses and helps repair damaged skin. Used in ointments to treat sunburns and minor burns, relieving itching and inflammation. Recommended dosage: 0.5% - 5%.

2. Hair Care Products

Enhances hair shine and elasticity, improves moisture retention and reduces combing damage.

3. Cosmetic Formulations

Widely used as a moisturizer and emollient in various creams, lotions and liquid foundations.

4. Pharmaceutical Field

Applied in topical preparations for promoting wound healing and skin repair.

Q1: What is DL-Panthenol?

A: DL-Panthenol (INCI Name: DL-Panthenol, Chemical Name: DL-Pantothenol, CAS 16485-10-2) is the alcohol derivative of pantothenic acid (Vitamin B5), a racemic mixture composed of equal amounts of D-panthenol and L-panthenol. It is available in two forms: white crystalline powder and transparent viscous liquid, and is readily soluble in water, ethanol and propylene glycol. It is one of the most widely used multifunctional active ingredients in the global cosmetics and pharmaceutical industries.

Q2: What is the difference between DL-Panthenol and D-Panthenol?

A: They are two distinct forms of panthenol with key differences:

Biological activity: Only D-panthenol is biologically active and can be converted to Vitamin B5 in the body. L-panthenol has no metabolic activity but still provides moisturizing benefits.

Physical form: D-panthenol is a clear viscous liquid, while DL-panthenol is primarily available as a white crystalline powder, which is easier to handle and measure in dry formulations.

Cost-effectiveness: DL-panthenol is more cost-effective than pure D-panthenol, making it ideal for mass-market products where high potency is not the primary requirement.

Applications: Both forms provide excellent moisturizing and conditioning effects, but D-panthenol is preferred for premium therapeutic formulations, while DL-panthenol is widely used in general skincare and haircare products.

Q3: How does DL-Panthenol work on skin and hair?

A: DL-Panthenol works through a dual mechanism:

Deep penetration: With a small molecular weight of approximately 205, it rapidly crosses the stratum corneum and penetrates deep into the epidermis and hair follicles.

Biological conversion: The D-isomer in DL-Panthenol is efficiently converted to Vitamin B5 (pantothenic acid) under the action of skin enzymes. Vitamin B5 is an essential component of coenzyme A, which is critical for skin cell metabolism, lipid synthesis and tissue repair.

This dual action delivers proven benefits including deep moisturization, skin barrier repair, wound healing acceleration and anti-inflammatory soothing.

Q4: What is the recommended dosage of DL-Panthenol?

A: Dosage varies by product type:

Creams, lotions & serums: 0.5% - 5.0%

Shampoos, conditioners & hair masks: 0.5% - 5.0%

Ointments & after-sun repair products: 1% - 5%

Body lotions & hand creams: 1% - 5%

Nail care products: 1% - 3%

Cosmetic & pharmaceutical preparations: Add as needed

Q5: Is DL-Panthenol safe for use in cosmetics and pharmaceuticals?

A: Yes, DL-Panthenol has an excellent safety profile and is globally approved for use:

CIR Safety Assessment: The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that panthenol (including DL-Panthenol) is safe for use in cosmetics at concentrations up to 5% .

Global regulatory approval: Approved by the US FDA, EU Cosmetics Regulation (EC) No 1223/2009 and listed in China's Inventory of Used Cosmetic Ingredients .

Low toxicity: It has extremely low acute toxicity and is non-sensitizing, non-irritating and non-phototoxic. It is safe for all skin types, including sensitive skin and baby skin.

Q6: What grades of DL-Panthenol do you offer?

A: As a professional source manufacturer, we provide multiple grades to meet different industry needs:

Cosmetic grade: ≥98% purity, suitable for general skincare and haircare products

USP grade: Meets United States Pharmacopoeia standards, ideal for high-end cosmetics and pharmaceutical preparations

Pharmaceutical grade: ≥99% purity, endotoxin-free, for medical devices and topical pharmaceutical products

Q7: What is the pH compatibility and formulation stability of DL-Panthenol?

A: DL-Panthenol exhibits excellent formulation stability:

Optimum pH range: 4.0 - 7.0, which covers the pH range of most cosmetic formulations .

Temperature stability: Stable at normal processing temperatures (up to 85°C). It is recommended to add it during the cool-down phase to preserve maximum activity.

Formulation impact: Within the recommended dosage range, it has minimal impact on the pH, viscosity or stability of the formulation system.

Q8: Is DL-Panthenol compatible with other cosmetic ingredients?

A: Yes, DL-Panthenol has exceptional compatibility with almost all cosmetic ingredients:

Surfactants: Fully compatible with anionic, cationic and non-ionic surfactants, allowing it to deposit effectively on skin and hair even in rinse-off products.

Active ingredients: Works synergistically with hyaluronic acid, niacinamide, centella asiatica and allantoin to enhance moisturizing, soothing and repair effects .

Other components: Compatible with emulsifiers, polymers, preservatives and botanical extracts.